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Updated April 16, 2007.

The aim of this page is to provide you with basic knowledge about Menopause. Some aspects of the management of menopauses are highly controversial. This page should only be used to provide information, and should never be used as a guide to self medicating yourself or others. Always contact a professional health care provider before changing your medication or treatment.

If we refer you to another page, most of the new pages will open in a new window. Just close the new window when you are finished and continue with this page.

Menopause occurs when both ovaries used up their egg cells. Egg cells are necessary for the ovary to function and to produce the hormones estrogen and progesterone. The way in which a normal ovary function is discussed under Normal Ovary.

Menopause also occurs when both ovaries are removed. This is sometimes necessary and women who lost their ovaries have the same symptoms as women where the menopause occurs naturally.

Menopause occurs normally between the ages of 45 - 55 years. (with some differences in different populations and in the reports of different researchers). This age is independent of the number of children, the use hormonal contraception (The Pill) or other factors. All women use up there egg cells at about the same age.

The pituitary gland still functions although the ovaries stopped functioning. The pituitary gland continues to try and stimulate the non responding ovaries. The levels of FSH and LH continue to increase in an effort to get to ovaries to respond. See The Pituitary Gland.

The lack of estrogen causes the symptoms experienced by post menopausal women. The most common being hot flushes, dry vagina, tiredness, mood swings, night sweat and disrupted sleep (insomnia) The incidence and severity of the symptoms differs from to woman to woman.

There are also long term or late onset symptoms and complications, the most important being increased incidence of heart disease , osteoporosis and a possible effect on the onset of Alzheimer's disease. The long term effects will be discussed a bit later.

If the ovaries contains about 500 000 eggs at birth ,why are there no eggs left at the age of 50 ? Although only one egg is released every month , it appears that every day of a woman's life a few egg cells are ready to develop and if they are not stimulated, they degenerate and disappear. For an egg cell to be stimulated and for a follicle to start developing the hormonal conditions in the body must be perfect. Once a month the FSH and LH ratio are conductive to follicle development and egg cell ripening . During the rest of the month , before adolescence, while taking oral contraceptives or during pregnancy the internal conditions are not perfect and egg development won't occur. Degeneration of the eggs that are ready still continues. That's why it doesn't matter how many pregnancies a women had or for how long she took oral contraceptives, the menopause will still occur at the age of 50 . The time of the her first period also have no influence on her age when the menopause occurs.

The Endometrium during Menopause
This drawing illustrates the endometrium during a normal menopause.

As you can see the endometrium is very thin here, this is due to a lack of oestrogen. Compare this endometrium with the endometrium during the fertile years in Normal Menstration.

This drawing shows a post menopausal ovary.
There are no egg cells or primary follicles in the ovary. Only scar tissue is present where the egg cells use to be. Scar tissue shrinks with time and this causes the ovaries to become smaller. Compare this ovary with the ovaries during the fertile years in The Normal Ovary.
Hormonal Replacement Therapy (HRT) during Menopause
Read our recent newsletter for more information and a discussion about the recent media reports concerning HRT.

What is meant by hormonal replacement therapy (HRT)? It is the artificial replacement of the hormone estrogen . This replacement can be taken in different forms. It can be taken orally (tablets). It is also possible to administer it through the skin (via patches that stick to the skin or ointments applied to the skin). It can also be injected or implanted underneath the skin.

The abbreviation HRT is used on this page and refers to hormonal replacement therapy.

Should a post menopausal woman use HRT? This is presently a controversial subject. Each individual should decide for herself, but she should be able to make an informed decision. We will discuss the advantages and disadvantages and also refer you to other sites in order to help you to make a decision.

You will see that there are risks both ways. There are certain risks when not taking HRT and other risks when taking hormonal replacement.

Advantages of HRT

1 Preventing Osteoporosis
Oestrogen slows down the reabsorption of bone and this prevent osteoporosis. It might also help to improve bone mass and density in women that are already at risk for having fractures. Osteoporosis is discussed in more detail in on this page.

2 Preventing Ischemic Heart Disease
Ischemic heart disease and coronary artery thrombosis is rare in pre menopausal (before the menopause) women. Following the menopause there is a sharp increase in the incidence of these deceases . There is strong evidence that the use of HRT helps to keep the incidence of ischemic heart diseases low at the pre menopausal level. It also seems that HRT must be started early, at the onset of the menopause , to be effective. It is to late and will probably have no beneficial effect if the coronary arteries are already effected and sick. Than there is a even an increased risk of thrombosis. The coronary arteries are the arteries that supply blood to the heart muscle.

About four times more women die from heart attacks after the menopause than from breast cancer. It is still to early to say if HRT will decreased the incidence of heart attacks. At this stage ( early 2002) it appears that if a women with a healthy heart at menopause start using HRT it will reduce her risk of ischemic heart disease. If however her heart is already effected or if she starts HRT after a heart attack it will not reduce her risk of further heart attacks.

This is presently a highly controversial subject. Many of the latest research cast doubt on the effectiveness of HRT in preventing heart attacks and strokes. Some criticism against studies showing an increase in heart attacks and strokes, is that there is doubt about the age at which the HRT commence. Was there already blood vessel damage when HRT was started?

Please refer to our August 2002 Newsletter and get the latest information.

We know if the experts are in doubt and not in complete agreement , how unsure must a lay person feel. Research is continuing and we hope to be able to have a clear answer in the near future.

3 Delaying the Onset of Alzheimer's Disease
There is more and more evidence indicating that HRT delay or postpone the onset of Alzheimer's disease. This is also not proven beyond doubt and more research are required.

4 Possible decrease in the Risk of Developing Colon Cancer
There is more and more evidence indicating that HRT delay or postpone the onset of Alzheimer's disease. This is also not proven beyond doubt and more research are required.

5 Relief of the menopausal and post menopausal symptoms
Hot flushes, dryness of the vagina, painful sexual intercourse, emotional disturbances ( difficulty controlling emotions), insomnia and dry skin are some of the common symptoms. HRT effectively reliefs all these symptoms.

Disadvantages of HRT

1 Effects on the Breasts
HRT and its effects on the breasts are presently a widely debated and discussed controversial topic. The main issue is DOES HRT USAGE INCREASES THE RISK OF BREAST CANCER?

If all the presently available knowledge and research data are analyzed we think that the following discussion accurately reflects and summarizes our present situation:

A. HRT probably does not change a normal cell into a cancer cell.

B. HRT will stimulate cancer cells that are already present to grow quicker. It accelerates breast cancer growth. Many researchers believe cancer is a slow disease at its onset and that it may take up to eight years for a cancerous breast lump to become palpable. WHEN THE LUMP IS DISCOVERED THE ABNORMALITY IS PROBABLY PRESENT FOR SEVERAL YEARS.

C This stimulating effect on cancer cells could create an impression that the incidence of breast cancer is slightly increased in women on HRT.

D. Women on HRT usually go for annual checkups and mammography. Cancer are therefore diagnosed early and this can also create an impression of a higher incidence of cancer.

E. Breast cancer is usually diagnosed earlier in on women on HRT than in women not taking any hormonal supplements.

F. The prognosis of women developing breast cancer while taking HRT is better than those who are develop it without taking HRT.

The points mentioned above are just impressions and not absolute facts. Thus is a controversial issue. Controlled research into the matter is complicated because the people most likely to use HRT are also the ones more likely to go for regular check ups and are most likely more health conscience. To get proper answers in any research project you need control groups with life styles as near as possible to the group that are being tested. The women on HRT and the control group not using HRT must be properly matched to get a reliable answer.

Another complicating factor is the fact that the risk of breast cancer increases with age. The age of onset of menopause might also play role ( the effects of the normal production of estrogen during the fertile life). The previous use of oral contraceptives is another factor to take into account. There are also other substances with estrogenic effects present in nature ( in plants). An example is soy sauce which have an estrogenic effect tissue. The intake of these substances might also influence the development of breast cancer. ( It is believed that some of them do not have estrogenic effects on the breasts and might have a protective effect against breast cancer)( see SERMS a bit later.)

The present controversies are probably due to (at least in part) to the factors discussed above. On fact is however clear from our present knowledge and that is if HRT usage increases the risk of breast cancer, than it is only a small increase in the risk. The risk is very small during the first ten years of HRT usage.

2 Effects on Blood Clotting
HRT usage increase the risk of intravascular coagulation, the formation of blood clots in the veins , especially the veins of the lower limbs ( legs) There is also an increase risk of strokes ( clots in the brains blood vessels. This risk is increased in smokers, persons with a history of previous blood clots and in people who are physically less active.(physical activity keeps blood circulating and helps to prevent blood from clotting in the blood vessels. Women taking HRT should always inform their surgeons and anesthetist about it before undergoing operations.

In a healthy non smoking women with a normal or low blood pressure it is doubtful of the risk is of any significance.

To Take or Not To Take HRT
The final decision rest with you. Carefully weigh the evidence and the risks. It is also important to consult your doctor. The following paragraphs will just give an overview of present thinking. Since this site was compiled new evidence emerged and we are in the process of rewriting this page. This will be an ongoing process a new data keeps on emerging. Please refer to our August 2002 newsletter for more information.

Presently: Most experts advise the use of HRT for the first five years following the menopause and to individualize each case. The symptoms, medical history and present heath should be taking into account before a final decision.

If a women has uterus than progesterone should be added to the supplement. ( either continuously or at least for ten days during each cycle). The continuous use of progesterone is now doubtful due to new evidence. Until there is more clear evidence we advise that the continuous use of progesterone ( taking a progesterone containing tablet every day) should be stopped . Refer to our August 2002 newsletter for more information

Following a five year periods: The treatment is than reviewed and the use of drugs known as SERM ( Selective Estrogen Receptor Modulators) should than be considered.

Hormones influences our bodies via areas on the walls of our cells known as receptors. The hormone binds or react with these receptors and causes some chemical changes in the cell. The hormone will only effect cells with receptors that will accept and react with it.

There are two kinds of estrogen receptors. The one kind is present in the uterus, vagina, bladder and the breast. The other kind is present in the rest of the body like bone tissue. A drug that stimulates only the receptors in other parts of the body and not the breasts, uterus, vagina and bladder is known as a SERM.

A SERM will have some of the advantages , heart attacks and probably postpone the onset of osteoporosis A disadvantage is that hot flushes , dry vagina and other symptoms may recur. This is one of the reasons why SERM are usually only prescribed later yin post menopausal life.

One last comment. All medicines have their origin in natural products. They are either purified extracts of plant or animal material, or modified copies of natural occurring substances. Therefor if so called "natural products" are effective they should have the same side effects. The only difference will be that they are less purified (?more natural) and therefor less potent .

OSTEOPEROSIS
We will now discuss the basic facts of osteoporosis.

Osteoporosis is a bone disease that causes bone to become fragile and brittle. This causes bone to fracture easily. There are many causes of osteoporosis , but on this page we are only concerned about the menopause.

Our bodies are constantly changing. Old tissue are destroyed and replaced by new tissue. This also occurs in living bone. Cells called osteoclasts constantly eats away old bone, creating tiny cavities in bone tissue. Another kind of cells , known as osteoblasts constantly forms new bone tissue and fills up these cavities. The net result is that bone loss and bone formation occurs at the same rate in the adult human. There is an equilibrium between bone reabsorption and bone formation.

The hormone estrogen is one the substances responsible for the formation of new bone tissue. The lack of estrogen after menopause slows down the formation of new bone, the cavities in the bone enlarged and the bone becomes brittle. The vertebrae , the neck of the thigh bone and the wrist ( actually the lower part of the radius) is most commonly effected.

A GRAPHIC PRESENTATION OF OSTEOPEROSIS
This drawing illustrates normal healthy bone tissue as seen through a microscope. The cavities are small.

The black areas represent the cavities were old bone was absorbed. The blue gray areas represent the formation of new bone, filling the cavities.

The next drawing illustrates the lack of new bone formation, causing the cavities to become very large. The is a marked decrease in bone tissue. This is osteoporosis.

The next drawing illustrates a part of the spine. Four vertebrae and three discs are shown.

The next drawing illustrates a decrease in bone mass in the vertebrae. The beginning of osteoporosis.

The next drawing illustrates a compressed fracture of one of the vertebrae. This is why it is important to try and prevent the development of osteoporosis.

Further reading
Remember this is at the moment controversial, a lot of research projects are studying the menopause and even the experts are still learning.
Menopause on Line
Beyond Menopause
Menopause and osteoperosis
Early menopause
Infomation about Menopause